diff --git a/CMakeLists.txt b/CMakeLists.txt
index 9051ecbd3318b7567d65563d2abb38f91214756e..6be4e23f44a6b6fda0cd6456fe62645a6c0c770e 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -29,6 +29,12 @@ if(NOT TARGET genopts_virtualenv)
     DEPENDS ${GENOPTS_VIRTUALENV}
     DEPENDS ${CMAKE_CURRENT_LIST_DIR}/requirements.txt
   )
+
+  # Ensure the virtual environment is removed when cleaning
+  set_property(
+    TARGET genopts_virtualenv
+    APPEND
+    PROPERTY ADDITIONAL_CLEAN_FILES ${GENOPTS_VIRTUALENV})
 endif()
 
 # Export a target with the location of the script in case someone needs this